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<p class="p_c_title2 js_editor_click deep "> <a href="/product/7/" target="_blank"> <span>鐢叉哀鍩鸿仛涔欎簩閱囪鐢熺墿</span> </a> </p> <ul class="p_c_content deep-3"> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/84/" target="_blank"> <span>M-PEG-SCM</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/85/" target="_blank"> <span>M-PEG-CM</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/86/" target="_blank"> <span>M-PEG-SPA</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/88/" target="_blank"> <span>M-PEG-SHA</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/89/" target="_blank"> <span>M-PEG-HA</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/90/" target="_blank"> 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href="/product/97/" target="_blank"> <span>M-PEG-VS</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/98/" target="_blank"> <span>M-PEG-SH</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/99/" target="_blank"> <span>M-PEG-ALD</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/100/" target="_blank"> <span>M-PEG-NH2HCl</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/101/" target="_blank"> <span>M-PEG-ACLT</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/102/" target="_blank"> <span>M-PEG-AZIDE</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/103/" target="_blank"> <span>M-PEG-ALKYNE</span> </a> </p> </li> <li class="p_c_item"> <p 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</p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/111/" target="_blank"> <span>M-PEG-PHOS</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/197/" target="_blank"> <span>M-PEG-GLU2</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/199/" target="_blank"> <span>M-PEG-BA</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/200/" target="_blank"> <span>M-PEG-SBA</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/201/" target="_blank"> <span>M-PEG-PA</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/202/" target="_blank"> <span>M-PEG-GLU3</span> </a> </p> </li> </ul> </li> <li class="p_c_item"> <p class="p_c_title2 js_editor_click deep "> <a href="/product/9/" target="_blank"> <span>鍚屽畼鑳藉洟鍙屽彇浠EG琛嶇敓鐗?/span> </a> </p> <ul class="p_c_content deep-3"> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/21/" target="_blank"> <span>NH2HCl-PEG-NH2HCl</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/22/" target="_blank"> <span>ACLT-PEG-ACLT</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/23/" target="_blank"> <span>ALKYNE-PEG-ALKYNE,</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/24/" target="_blank"> <span>CM-PEG-CM</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/25/" target="_blank"> <span>MAL-PEG-MAL</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/26/" target="_blank"> <span>SCM-PEG-SCM</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/27/" target="_blank"> <span>HS-PEG-SH</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/28/" target="_blank"> <span>VS-PEG-VS</span> </a> </p> </li> </ul> </li> <li class="p_c_item"> <p class="p_c_title2 js_editor_click deep "> <a href="/product/10/" target="_blank"> <span>寮傚畼鑳藉洟鍙屽彇浠EG琛嶇敓鐗?/span> </a> </p> <ul class="p_c_content deep-3"> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/37/" target="_blank"> <span>ACLT-PEG-SCM</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/38/" target="_blank"> <span>NH2HCl-PEG-CM</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/39/" target="_blank"> <span>ALKYNE-PEG-MAL</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/40/" target="_blank"> <span>AZIDE-PEG-SCM</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/41/" target="_blank"> <span>AZIDE-PEG-NH2TFA</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/42/" target="_blank"> <span>BIOTIN-PEG-MAL</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/43/" target="_blank"> <span>BIOTIN-PEG-SCM</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/44/" target="_blank"> <span>BIOTIN-PEG-SGA</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/45/" target="_blank"> <span>FMOC-PEG-NH2TFA</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/46/" target="_blank"> <span>FMOC-PEG-CM</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/47/" target="_blank"> <span>FMOC-PEG-OH</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/48/" target="_blank"> <span>FMOC-PEG-SCM</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/49/" target="_blank"> <span>HO-PEG-NH2HCl</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/50/" target="_blank"> <span>HO-PEG-CM</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/51/" target="_blank"> <span>HO-PEG-SCM</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/52/" target="_blank"> <span>HO-PEG-PA</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/53/" target="_blank"> 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<p>鍦板潃锛氬寳浜競娴锋穩鍖鸿タ灏忓彛璺?6鍙蜂腑鍏虫潙涓滃崌绉戞妧鍥瑿-1妤间笁灞侟/p> </div></div> </div></div> </div> <input type="hidden" name="propJson" value='{"onpenAll_4":false,"href_5":{"type":"none","value":"","target":""},"href_7":{"type":"none","value":"","target":""},"aiSet_15":{"contentKeywords":"鐢熸垚涓€娈?{{鍏徃鍚嶇О}}${{琛屼笟}}鐨勫叕鍙哥畝浠嬪唴瀹?quot;,"type":1},"showImg_4":false,"aiSet_14":{"contentKeywords":"鐢熸垚涓€娈?{{鍏徃鍚嶇О}}${{琛屼笟}}鐨勫叕鍙哥畝浠嬪唴瀹?quot;,"type":1},"prompt_5":"","prompt_7":"","aiSet_7":{"contentKeywords":"鐢熸垚涓€娈?{{鍏徃鍚嶇О}}${{琛屼笟}}鐨勫叕鍙哥畝浠嬪唴瀹?quot;,"type":1},"dense_5":"","aiSet_5":{"contentKeywords":"鐢熸垚涓€娈?{{鍏徃鍚嶇О}}${{琛屼笟}}鐨勫叕鍙哥畝浠嬪唴瀹?quot;,"type":1},"dense_7":""}'/></div></div> <div id="content_box-1682664323660-1" class="d_gridCell_1 p_gridCell"><div id="c_product_detail_003_P_016-1654754902235"> <div class="e_container-2 s_layout"> <div class="cbox-2-0 p_item"><div class="e_magnifier-40 s_list" needjs="true"> <div class="magnifier thumb_bottom" id="magnifierWrapper"> <div class="magnifier-container">  <div class="images-cover"> <div class="image-item"> <img src="/npublic/img/s.png" lazy="https://omo-oss-image.thefastimg.com/portal-saas/new2023042821215034000/cms/image/c64967d8-9ef4-4cf5-aa14-a6e7816f63dc.png" alt="undefined" title="undefined" la="la"/> </div> </div>  <div class="image-bigger"> <div class="add-icon">+</div> </div>  <ul class="p_tabName"> <li class="js_nameItem p_nameItem active "> 浜у搧鎻忚堪 </li> <li class="js_nameItem p_nameItem "> 鍙傝€冩枃鐚 </li> </ul>  <ul class="p_tabContent">  <li class="p_contentItem active">  <div class="p_infoItem"> <div class="reset_style js-reset_style js-adapMobile "> <p>銆€銆€閿嚡绉戞妧鎻愪緵楂樺搧璐ㄩ偦浜岀～鍚″暥鑱氫箼浜岄唶鐞ョ弨閰颁簹鑳虹晶鐢插熀閰紝浜у搧鍙栦唬鐜?gt;90%銆侟/p> <p>銆€銆€閿嚡绉戞妧鐢熶骇鐨勫紓鍙屽姛鑳藉矾鍩哄悺鍟禤EG鐞ョ弨閰颁簹鑳哄熀缇х敳鍩洪叝浜у搧閫氬父鐢ㄤ綔涓ょ涓嶅悓鍖栧鐗╄川鐨勪氦鑱斿墏鎴栭棿闅旂墿銆傛寮傚姛鑳絇EG琛嶇敓鐗╀腑鐨凱EG閮ㄥ垎鍙彁渚涙按婧舵€с€佺敓鐗╃浉瀹规€у強鏌旀€с€傛浜у搧涓撻棬搴旂敤浜庢姉浣撳伓鑱旇嵂鐗?ADC’s)鐨勫紑鍙戙€侟/p> <p>銆€銆€閿嚡绉戞妧鎻愪緵OPSS-PEG-SCM浜у搧鐨勫父瑙勫垎瀛愰噺鏄?000 Da,3500 Da, 5000 Da, 7500 Da鐨勫绉嶈鏍煎寘瑁呬骇鍝併€侟/p> <p>銆€銆€閿嚡绉戞妧鍚屾椂鎻愪緵鍏朵粬鍒嗗瓙閲忕殑OPSS-PEG-SCM琛嶇敓鐗╀骇鍝侊紝濡備綘闇€瑕佽涓庢垜鍙竤ales@jenkem.com鑱旂郴銆侟/p> <p> 閿嚡绉戞妧鎻愪緵鍒嗚鏈嶅姟锛岄渶瑕佹敹鍙栧垎瑁呰垂鐢紝濡傛灉鎮ㄩ渶瑕佸垎瑁呬负鍏朵粬瑙勬牸璇蜂笌鎴戜滑鑱旂郴銆侟/p> <p>銆€ 閿嚡绉戞妧鎻愪緵澶ф壒閲忕敓浜т骇鍝佸強GMP绾у埆浜у搧锛屽闇€鎶ヤ环璇蜂笌鎴戜滑鑱旂郴銆侟/p> </div> </div> </li>  <li class="p_contentItem"> <p><font face="Arial">銆€銆€References:</font></p> <p><font face="Arial">銆€銆€1. Ye, J., et al., Cellular uptake mechanism and comparative in vitro cytotoxicity studies of monomeric LMWP-siRNA conjugate, Journal of Industrial and Engineering Chemistry, 2018.</font></p> <p><font face="Arial">銆€銆€2. Lee, K., et al., Enhanced accumulation of theranostic nanoparticles in brain tumor by external magnetic field mediated in situ clustering of magnetic nanoparticles, Journal of Industrial and Engineering Chemistry, 2017.</font></p> <p><font face="Arial">銆€銆€3. Feng, Y., et al., Evaluation of Electrospun PCL-PIBMD Meshes Modified with Plasmid Complexes in Vitro and in Vivo. Polymers, 2016, 8(3), p.58.</font></p> <p><font face="Arial">銆€銆€4. Braun, G.B., et al., Urokinase-controlled tumor penetrating peptide. Journal of Controlled Release, 2016, 232:188-95.</font></p> <p><font face="Arial">銆€銆€5. Shin M.C., et al., Preparation and Characterization of Gelonin-Melittin Fusion Biotoxin for Synergistically Enhanced Anti-Tumor Activity. Pharmaceutical research, 2016, 1-1.</font></p> <p><font face="Arial">銆€銆€6. Zhou, F., et al., Targeted delivery of microRNA-126 to vascular endothelial cells via REDV peptide modified PEG-trimethyl chitosan. Biomaterials science, 2016, 4(5):849-56.</font></p> <p><font face="Arial">銆€銆€7. Sugahara, K.N., et al., Tumor-Penetrating iRGD Peptide Inhibits Metastasis, Mol. Cancer Ther., 2015, 14, 120.</font></p> <p><font face="Arial">銆€銆€8. Wang, H., et al., Targeting REDV peptide functionalized polycationic gene carrier for enhancing the transfection and migration capability of human endothelial cells, J. Mater. Chem. B, 2015, 3, 3379-3391.</font></p> <p><font face="Arial">銆€銆€9. Braun, G.B., Etchable and Bright Silver Nanoparticle Probes for Cell Internalization Assays, Nature Materials, 2014, 13, p: 904–911.</font></p> <p><font face="Arial">銆€銆€10. Pang, H.B., et al., An endocytosis pathway initiated through 鈥媙europilin-1 and regulated by nutrient availability, Nature Communications, 2014, 5:4904.</font></p> <p><font face="Arial">銆€銆€11. Shin, M.C., et al., Combination of antibody targeting and PTD-mediated intracellular toxin delivery for colorectal cancer therapy, Journal of Controlled Release, 194(28), 2014, p: 197-210.</font></p> <p><font face="Arial">銆€銆€12. Minai, L., et al., High levels of reactive oxygen species in gold nanoparticle-targeted cancer cells following femtosecond pulse irradiation, Scientific Reports, 2013, 3 : 2146.</font></p> <p><font face="Arial">銆€銆€13. Yeheskely-Hayon, D., et al., Optically Induced Cell Fusion Using Bispecific Nanoparticles, Small, 2013.</font></p> <p><font face="Arial">銆€銆€14. Agemy, L., et al., Targeted nanoparticle enhanced proapoptotic peptide as potential therapy for glioblastoma PNAS, 2011, 108(42), 17450-17455.</font></p> <p><font face="Arial">銆€銆€15. Whaley Bishnoi, S., et al., SERS Biodetection Using Gold–Silica Nanoshells and Nitrocellulose Membranes, Analytical Chemistry, 2011, 83(11), p: 4053–4060.</font></p> <p><font face="Arial"> 16.Laskar, P, et al., Octadecyl chain-bearing PEGylated poly (propyleneimine)-based dendrimersomes: physicochemical studies, redox-responsiveness, DNA condensation, cytotoxicity and gene delivery to cancer cells. Biomaterials Science. 2021, 9(4):1431-48.</font></p> <p> 17.Tobi, A, et al., Silver nanocarriers targeted with a CendR peptide potentiate the cytotoxic activity of an anticancer drug. Advanced Therapeutics. 2021, 4(1):2000097.</p> <p> 18.Pleiko, K, et al., In vivo phage display: identification of organ-specific peptides using deep sequencing and differential profiling across tissues. 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