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<p class="p_c_title2 js_editor_click deep "> <a href="/product/7/" target="_blank"> <span>鐢叉哀鍩鸿仛涔欎簩閱囪鐢熺墿</span> </a> </p> <ul class="p_c_content deep-3"> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/84/" target="_blank"> <span>M-PEG-SCM</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/85/" target="_blank"> <span>M-PEG-CM</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/86/" target="_blank"> <span>M-PEG-SPA</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/88/" target="_blank"> <span>M-PEG-SHA</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/89/" target="_blank"> <span>M-PEG-HA</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/90/" target="_blank"> 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href="/product/97/" target="_blank"> <span>M-PEG-VS</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/98/" target="_blank"> <span>M-PEG-SH</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/99/" target="_blank"> <span>M-PEG-ALD</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/100/" target="_blank"> <span>M-PEG-NH2HCl</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/101/" target="_blank"> <span>M-PEG-ACLT</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/102/" target="_blank"> <span>M-PEG-AZIDE</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/103/" target="_blank"> <span>M-PEG-ALKYNE</span> </a> </p> </li> <li class="p_c_item"> <p 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</p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/111/" target="_blank"> <span>M-PEG-PHOS</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/197/" target="_blank"> <span>M-PEG-GLU2</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/199/" target="_blank"> <span>M-PEG-BA</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/200/" target="_blank"> <span>M-PEG-SBA</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/201/" target="_blank"> <span>M-PEG-PA</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/202/" target="_blank"> <span>M-PEG-GLU3</span> </a> </p> </li> </ul> </li> <li class="p_c_item"> <p class="p_c_title2 js_editor_click deep "> <a href="/product/9/" target="_blank"> <span>鍚屽畼鑳藉洟鍙屽彇浠EG琛嶇敓鐗?/span> </a> </p> <ul class="p_c_content deep-3"> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/21/" target="_blank"> <span>NH2HCl-PEG-NH2HCl</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/22/" target="_blank"> <span>ACLT-PEG-ACLT</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/23/" target="_blank"> <span>ALKYNE-PEG-ALKYNE,</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/24/" target="_blank"> <span>CM-PEG-CM</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/25/" target="_blank"> <span>MAL-PEG-MAL</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/26/" target="_blank"> <span>SCM-PEG-SCM</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/27/" target="_blank"> <span>HS-PEG-SH</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/28/" target="_blank"> <span>VS-PEG-VS</span> </a> </p> </li> </ul> </li> <li class="p_c_item"> <p class="p_c_title2 js_editor_click deep "> <a href="/product/10/" target="_blank"> <span>寮傚畼鑳藉洟鍙屽彇浠EG琛嶇敓鐗?/span> </a> </p> <ul class="p_c_content deep-3"> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/37/" target="_blank"> <span>ACLT-PEG-SCM</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/38/" target="_blank"> <span>NH2HCl-PEG-CM</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/39/" target="_blank"> <span>ALKYNE-PEG-MAL</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/40/" target="_blank"> <span>AZIDE-PEG-SCM</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/41/" target="_blank"> <span>AZIDE-PEG-NH2TFA</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/42/" target="_blank"> <span>BIOTIN-PEG-MAL</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/43/" target="_blank"> <span>BIOTIN-PEG-SCM</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/44/" target="_blank"> <span>BIOTIN-PEG-SGA</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/45/" target="_blank"> <span>FMOC-PEG-NH2TFA</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/46/" target="_blank"> <span>FMOC-PEG-CM</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/47/" target="_blank"> <span>FMOC-PEG-OH</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/48/" target="_blank"> <span>FMOC-PEG-SCM</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/49/" target="_blank"> <span>HO-PEG-NH2HCl</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/50/" target="_blank"> <span>HO-PEG-CM</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/51/" target="_blank"> <span>HO-PEG-SCM</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/52/" target="_blank"> <span>HO-PEG-PA</span> </a> </p> </li> <li class="p_c_item"> <p class="p_c_title3 js_editor_click deep "> <a href="/product/53/" target="_blank"> 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<p>鍦板潃锛氬寳浜競娴锋穩鍖鸿タ灏忓彛璺?6鍙蜂腑鍏虫潙涓滃崌绉戞妧鍥瑿-1妤间笁灞侟/p> </div></div> </div></div> </div> <input type="hidden" name="propJson" value='{"onpenAll_4":false,"href_5":{"type":"none","value":"","target":""},"href_7":{"type":"none","value":"","target":""},"aiSet_15":{"contentKeywords":"鐢熸垚涓€娈?{{鍏徃鍚嶇О}}${{琛屼笟}}鐨勫叕鍙哥畝浠嬪唴瀹?quot;,"type":1},"showImg_4":false,"aiSet_14":{"contentKeywords":"鐢熸垚涓€娈?{{鍏徃鍚嶇О}}${{琛屼笟}}鐨勫叕鍙哥畝浠嬪唴瀹?quot;,"type":1},"prompt_5":"","prompt_7":"","aiSet_7":{"contentKeywords":"鐢熸垚涓€娈?{{鍏徃鍚嶇О}}${{琛屼笟}}鐨勫叕鍙哥畝浠嬪唴瀹?quot;,"type":1},"dense_5":"","aiSet_5":{"contentKeywords":"鐢熸垚涓€娈?{{鍏徃鍚嶇О}}${{琛屼笟}}鐨勫叕鍙哥畝浠嬪唴瀹?quot;,"type":1},"dense_7":""}'/></div></div> <div id="content_box-1682664323660-1" class="d_gridCell_1 p_gridCell"><div id="c_product_detail_003_P_016-1654754902235"> <div class="e_container-2 s_layout"> <div class="cbox-2-0 p_item"><div class="e_magnifier-40 s_list" needjs="true"> <div class="magnifier thumb_bottom" id="magnifierWrapper"> <div class="magnifier-container">  <div class="images-cover"> <div class="image-item"> <img src="/npublic/img/s.png" lazy="https://omo-oss-image.thefastimg.com/portal-saas/new2023042821215034000/cms/image/9d152913-3837-4e4b-9434-d0a9dcf06b89.png" alt="undefined" title="undefined" la="la"/> </div> </div>  <div class="image-bigger"> <div class="add-icon">+</div> </div>  <ul class="p_tabName"> <li class="js_nameItem p_nameItem active "> 浜у搧鎻忚堪 </li> <li class="js_nameItem p_nameItem "> 鍙傝€冩枃鐚 </li> </ul>  <ul class="p_tabContent">  <li class="p_contentItem active">  <div class="p_infoItem"> <div class="reset_style js-reset_style js-adapMobile "> <p>銆€銆€閿嚡绉戞妧鎻愪緵楂樺搧璐ㄩ┈鏉ラ叞浜氳兒鍩鸿仛涔欎簩閱囩緹鍩轰骇鍝侊紝浜у搧鍙栦唬鐜?ge;95%銆侟/p> <p>銆€銆€閿嚡绉戞妧鐢熶骇鐨勫紓鍙屽姛鑳介┈鏉ラ叞浜氳兒PEG缇熷熀浜у搧閫氬父鐢ㄤ綔涓ょ涓嶅悓鍖栧鐗╄川鐨勪氦鑱斿墏鎴栭棿闅旂墿銆傛寮傚姛鑳絇EG琛嶇敓鐗╀腑鐨凱EG閮ㄥ垎鍙彁渚涙按婧舵€с€佺敓鐗╃浉瀹规€у強鏌旀€с€傛浜у搧涓撻棬搴旂敤浜庢姉浣撳伓鑱旇嵂鐗?ADC’s)鐨勫紑鍙戙€侟/p> <p>銆€銆€閿嚡绉戞妧鎻愪緵MAL-PEG-OH鍒嗗瓙閲?000 Da,3500 Da, 5000 Da, 7500 Da鐨勪骇鍝?鍏嬪拰10鍏嬪寘瑁呫€侟/p> <p>銆€銆€閿嚡绉戞妧鎻愪緵鍒嗚鏈嶅姟锛岄渶瑕佹敹鍙栧垎瑁呰垂鐢紝濡傛灉鎮ㄩ渶瑕佸垎瑁呬负鍏朵粬瑙勬牸璇蜂笌鎴戜滑鑱旂郴銆侟/p> <p>銆€銆€閿嚡绉戞妧鍚屾椂鎻愪緵鍏朵粬鍒嗗瓙閲忕殑MAL-PEG-OH琛嶇敓鐗╀骇鍝侊紝濡備綘闇€瑕佽涓庢垜鍙竤ales@jenkem.com鑱旂郴銆侟/p> <p>銆€銆€閿嚡绉戞妧鎻愪緵澶ф壒閲忕敓浜т骇鍝佸強GMP绾у埆浜у搧锛屽闇€鎶ヤ环璇蜂笌鎴戜滑鑱旂郴銆侟/p> <p style="box-sizing: border-box; margin: 0px 0px 20px; color: rgb(73, 73, 73); font-family: Cairo, Arial, Helvetica, sans-serif; font-size: 17px; font-weight: 600; background-color: rgb(255, 255, 255);"> </p> </div> </div> </li>  <li class="p_contentItem"> <p><font face="Arial">銆€銆€References:</font></p> <p><font face="Arial">銆€銆€1. Xu, X., et al., Efficient and targeted drug/siRNA co-delivery mediated by reversibly crosslinked polymersomes toward anti-inflammatory treatment of ulcerative colitis (UC), Nano Research, 2019, 1-9.</font></p> <p><font face="Arial">銆€銆€2. Mozhi, A., et al., Nrp-1 receptor targeting peptide-functionalized TPGS micellar nanosystems to deliver 10-hydroxycampothecin for enhanced cancer chemotherapy, International Journal of Pharmaceutics, 2018, 547(1–2), P. 582-592.</font></p> <p><font face="Arial">銆€銆€3. Sarmanova, O.E., et al., A method for optical imaging and monitoring of the excretion of fluorescent nanocomposites from the body using artificial neural networks, Nanomedicine: Nanotechnology, Biology and Medicine, 2018, 14(4), pp.1371-1380.</font></p> <p><font face="Arial">銆€銆€4. Fang, Z., et al., Targeted osteosarcoma chemotherapy using RGD peptide-installed doxorubicin-loaded biodegradable polymeric micelle, Biomedicine & Pharmacotherapy, 2017, V. 85, P. 160-168.</font></p> <p><font face="Arial">銆€銆€5. Wang, Y., et al., Quantum-Dot-Based Theranostic Micelles Conjugated with an Anti-EGFR Nanobody for Triple-Negative Breast Cancer Therapy, ACS applied materials & interfaces, 2017, 9(36):30297-305.</font></p> <p><font face="Arial">銆€銆€6. Mondal, G., et al., EGFR-Targeted Polymeric Mixed Micelles Carrying Gemcitabine for Treating Pancreatic Cancer, Biomacromolecules, 2016, 17 (1), pp 301–313.</font></p> <p><font face="Arial">銆€銆€7. Li, C., et al., Design, preparation and characterization of cyclic RGDfK peptide modified poly (ethylene glycol)-block-poly (lactic acid) micelle for targeted delivery, Materials Science and Engineering: C, 2016.</font></p> <p><font face="Arial">銆€銆€8. Gu, D., et al., Amphiphilic core cross-linked star polymers as water-soluble, biocompatible and biodegradable unimolecular carriers for hydrophobic drugs, Polym. Chem., 2015, 6, 6475-6487.</font></p> <p><font face="Arial">銆€銆€9. Prabhakar, N., et al., Functionalization of graphene oxide nanostructures improves photoluminescence and facilitates their use as optical probes in preclinical imaging, Nanoscale, 2015, 7, 10410-10420.</font></p> <p><font face="Arial">銆€銆€10. Ding, G.-B., et al., Integrin αVβ3-Targeted Magnetic Nanohybrids with Enhanced Antitumor Efficacy, Cell Cycle Arrest Ability, and Encouraging Anti-Cell-Migration Activity, ACS Appl. Mater. Interfaces, 2014, 6 (19), p: 16643–16652.</font></p> <p><font face="Arial">銆€銆€11. Song, W., et al., Anti-tumor efficacy of c(RGDfK)-decorated polypeptide-based micelles co-loaded with docetaxel and cisplatin. Biomaterials, 2014, 35(9): p. 3005-3014.</font></p> <p><font face="Arial">銆€銆€12. Liu, J., et al., Effect of site-specific PEGylation on the fibrinolytic activity, immunogenicity, and pharmacokinetics of staphylokinase, Acta Biochim Biophys Sin, 2014, 46 (9): 782-791.</font></p> <p><font face="Arial">銆€銆€13. Li, Y., et al., Docetaxel-Encapsulating Small-Sized Polymeric Micelles with Higher Permeability and Its Efficacy on the Orthotopic Transplantation Model of Pancreatic Ductal Adenocarcinoma, Int. J. Mol. Sci., 2014, 15(12), 23571-23588.</font></p> <p><font face="Arial">銆€銆€14. Pridgen, E. M., et al., Transepithelial Transport of Fc -Targeted Nanoparticles by the Neonatal Fc Receptor for Oral Delivery, Sci Transl Med., 2013, 5(213).</font></p> <p><font face="Arial">銆€銆€15. Shen, J., et al., Poly(ethylene glycol)-block-poly(d,l-lactide acid) micelles anchored with angiopep-2 for brain-targeting delivery, Journal of Drug Targeting, 2011, 19:3.</font></p> <p><font face="Arial">銆€銆€16. 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