浜у搧涓績
鑱旂郴鎴戜滑
閿€鍞笓鐢細
鍦板潃锛氬寳浜競娴锋穩鍖鸿タ灏忓彛璺?6鍙蜂腑鍏虫潙涓滃崌绉戞妧鍥瑿-1妤间笁灞侟/p>

- 浜у搧鎻忚堪
- 鍙傝€冩枃鐚
-
銆€銆€閿嚡绉戞妧鐢熶骇鐨勫彅涓佹哀缇版皑鍩鸿仛涔欎簩閱囩惀鐝€閰颁簹鑳虹晶鐢插熀閰骇鍝佷腑鍚湁鍙梩Boc淇濇姢鐨勮兒鍩哄洟锛岄€氬父鐢ㄤ綔涓ょ涓嶅悓鍖栧鐗╄川鐨勪氦鑱斿墏鎴栭棿闅旂墿銆傛寮傚姛鑳絇EG琛嶇敓鐗╀腑鐨凱EG閮ㄥ垎鍙彁渚涙按婧舵€с€佺敓鐗╃浉瀹规€у強鏌旀€с€傛浜у搧涓撻棬搴旂敤浜庢姉浣撳伓鑱旇嵂鐗?ADC’s)鐨勫紑鍙戙€侟/p>
銆€銆€閿嚡绉戞妧鎻愪緵TBOC-PEG-SCM鍒嗗瓙閲?000 Da,3500 Da, 5000 Da, 7500 Da鐨勪骇鍝?鍏嬪拰10鍏嬪寘瑁呫€侟/p>
銆€銆€閿嚡绉戞妧鎻愪緵鍒嗚鏈嶅姟锛岄渶瑕佹敹鍙栧垎瑁呰垂鐢紝濡傛灉鎮ㄩ渶瑕佸垎瑁呬负鍏朵粬瑙勬牸璇蜂笌鎴戜滑鑱旂郴銆侟/p>
銆€銆€閿嚡绉戞妧鍚屾椂鎻愪緵鍏朵粬鍒嗗瓙閲忕殑TBOC-PEG-SCM琛嶇敓鐗╀骇鍝侊紝濡備綘闇€瑕佽涓庢垜鍙竤ales@jenkem.com鑱旂郴銆侟/p>
銆€銆€閿嚡绉戞妧鎻愪緵澶ф壒閲忕敓浜т骇鍝佸強GMP绾у埆浜у搧锛屽闇€鎶ヤ环璇蜂笌鎴戜滑鑱旂郴銆侟/p>
-
銆€銆€References:
銆€銆€1. Kuruvilla, S.P., et al., Effect of N-acetylgalactosamine ligand valency on targeting dendrimers to hepatic cancer cells, International journal of pharmaceutics, 2018, 545(1-2), pp.27-36.
銆€銆€2. Kuruvilla, S.P., et al., N-Acetylgalactosamine-Targeted Delivery of Dendrimer-Doxorubicin Conjugates Influences Doxorubicin Cytotoxicity and Metabolic Profile in Hepatic Cancer Cells, Adv. Healthcare Mater., 2017, 1601046.3.
銆€銆€3. Balasso, A., et al., Re-programming pullulan for targeting and controlled release of doxorubicin to the hepatocellular carcinoma cells, European Journal of Pharmaceutical Sciences, 2017.
銆€銆€4. Lu, J., et al., Targeted Delivery of Doxorubicin by Folic Acid-Decorated Dual Functional Nanocarrier, Mol. Pharmaceutics, 2014, 11(11), p: 4164–4178.
銆€銆€5. Tanwir, K., et al., Coexisting Phases in PEGylated Phosphocholine Membranes: A Model Study, Langmuir, 2012, 28(39), pp 14000–14009.
銆€銆€6. Zhang, Y., et al., Incorporation of a selective sigma-2 receptor ligand enhances uptake of liposomes by multiple cancer cells. Int J Nanomedicine, 2012, 7: p. 4473–4485.
銆€銆€7. Smolensky, E. D., et al., Magnetoluminescent Agents for Dual MRI and Time-Gated Fluorescence Imaging, European Journal of Inorganic Chemistry, 2012, (12): 2141-2147.
銆€銆€8. Smolensky, E. D., et al., A responsive particulate MRI contrast agent for copper(I): a cautionary tale, Dalton Trans., 2012, 41, 8039-8046.
銆€銆€9.Chen, Q., et al., Biodegradable nanoparticles decorated with different carbohydrates for efficient macrophage-targeted gene therapy, Journal of Controlled Release, 2020; 323:179-90.
浜у搧璇环