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銆€銆€References:
銆€銆€1. Ji, F., et al., A Dual pH/Magnetic Responsive Nanocarrier Based on PEGylated Fe3O4 Nanoparticles for Doxorubicin Delivery, Journal of Nanoscience and Nanotechnology, 2018, 18.7: 4464-4470.
銆€銆€2. Xiao, S., et al., Aptamer-mediated gene therapy enhanced antitumor activity against human hepatocellular carcinoma in vitro and in vivo, Journal of Controlled Release, 2017.
銆€銆€3. Jing, P., et al, Enhanced growth inhibition of prostate cancer in vitro and in vivo by a recombinant adenovirus-mediated dual-aptamer modified drug delivery system, Cancer Letters, 2016, V. 383(2), P. 230-242.
銆€銆€4. Lorenzo, M. M., et al., Homodimeric Protein–Polymer Conjugates via the Tetrazine–trans-Cyclooctene Ligation, Macromolecules, 2015.
銆€銆€5. Xue, Y., et al., Quantifying thiol–gold interactions towards the efficient strength control, Nature communications, 2014, 5.
銆€銆€6. Xu, P., et al., Hydrogen-bonded and reduction-responsive micelles loading atorvastatin for therapy of breast cancer metastasis. Biomaterials, 2014, 35(26): p. 7574-7587.
銆€銆€7. Gajbhiye, V., et al., Drug-loaded nanoparticles induce gene expression in human pluripotent stem cell derivatives. Nanoscale, 2014, 6(1): p. 521-31.
銆€銆€8. Gao, X., et al., Prostate stem cell antigen-targeted nanoparticles with dual functional properties: in vivo imaging and cancer chemotherapy. Int J Nanomedicine, 2012, 7: p. 4037-51.
銆€銆€9銆乄ang, C., et al., Synthesis and formation mechanism of bone mineral, whitlockite nanocrystals in tri-solvent system, Journal of Colloid and Interface Science, 2020, V. 569, P. 1-11.
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