浜у搧涓績
鑱旂郴鎴戜滑
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鍦板潃锛氬寳浜競娴锋穩鍖鸿タ灏忓彛璺?6鍙蜂腑鍏虫潙涓滃崌绉戞妧鍥瑿-1妤间笁灞侟/p>

- 浜у搧鎻忚堪
- 鍙傝€冩枃鐚
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銆€銆€閿嚡绉戞妧鍚屾椂鎻愪緵鍏朵粬鍒嗗瓙閲忕殑M-SH浜у搧锛屽浣犻渶瑕佽涓庢垜鍙竤ales@jenkem.com鑱旂郴銆侟/p>
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銆€銆€References:
銆€銆€1. Zhang, J., et al., Real-time and in-situ monitoring of Abrin induced cell apoptosis by using SERS spectroscopy, Talanta, 2019, V. 195, P. 8-16.
銆€銆€2. Li, X., et al., Efficient biofunctionalization of MoS2 nanosheets with peptides as intracellular fluorescent biosensor for sensitive detection of caspase-3 activity, Journal of Colloid and Interface Science, 2019.
銆€銆€3. Han, L., et al., Surface-enhanced resonance Raman scattering guided brain tumor surgery showing prognostic benefit in rat models, ACS applied materials & interfaces, 2019.
銆€銆€4. Xu, W., et al., PEGylated hydrazided gold nanorods for pH-triggered chemo/ photodynamic/ photothermal triple therapy of breast cancer, Acta Biomaterialia, 2018, V. 82, P. 171-183.
銆€銆€5. DiTullio, B.T., et al., Surface modification of polyaniline nanorods with thiol-terminated poly (ethylene oxide), Colloid and Polymer Science, 2018, 296(4), pp.637-645.
銆€銆€6. Luan, J., et al., Environmental Stability of Plasmonic Biosensors based on Natural vs. Artificial Antibody, Analytical chemistry, 2018.
銆€銆€7. Shao, B., et al., Nanogapped Au (core)@ Au-Ag (shell) structures coupled with Fe3O4 Magnetic nanoparticles for the detection of Ochratoxin A., Analytica Chimica Acta, 2018.
銆€銆€8. Wang, Y., et al., Enzymatically driven formation of palindromic DNA-Au nanoparticles for snowball assembly and colorimetric biosensing, Sensors and Actuators B: Chemical, 2018, 267, pp.328-335.
銆€銆€9. Su, B., et al., Effect of Retro鈥怚nverso Isomer of Bradykinin on Size鈥怐ependent Penetration of Blood–Brain Tumor Barrier, Small, 2018.
銆€銆€10. Peng, G., at al., N-terminal site-specific PEGylation enhances the circulation half-life of Thymosin alpha 1, Journal of Drug Delivery Science and Technology, 2018.
銆€銆€11. Li, H., et al., Combination of active targeting, enzyme-triggered release and fluorescent dye into gold nanoclusters for endomicroscopy-guided photothermal/photodynamic therapy to pancreatic ductal adenocarcinoma, Biomaterials, 2017.
銆€銆€12. Liu, D., et al., A Fully Integrated Distance Readout ELISA-Chip for Point-of-Care Testing with Sample-in-Answer-out Capability, Biosensors and Bioelectronics, 2017.
銆€銆€13. Yue, Q., et al., An EGFRvIII targeted dual-modal gold nanoprobe for imaging-guided brain tumor surgery, Nanoscale, 2017.
銆€銆€14. Kampert, T., et al., Phenotypically Screened Carbon Nanoparticles for Enhanced Combinatorial Therapy in Triple Negative Breast Cancer, Cellular and Molecular Bioengineering, 2017, 1-6.
銆€銆€15. Billingsley, M.M., et al., Antibody-nanoparticle conjugates to enhance the sensitivity of ELISA-based detection methods, PloS one, 2017, 12(5):e0177592.
銆€銆€16. Li, S.S., et al., Revealing chemical processes and kinetics of drug action within single living cells via plasmonic Raman probes, Scientific Reports, 2017, 7.
銆€銆€17. Srivastava, I., et al., Surface chemistry of carbon nanoparticles functionally select their uptake in various stages of cancer cells, Nano Research, 2017, 1-6.
銆€銆€18. Ni, D., et al., Oxygen Vacancy Enables Markedly Enhanced Magnetic Resonance Imaging-Guided Photothermal Therapy of a Gd (3+)-Doped Contrast Agent, ACS Nano, 2017.
銆€銆€19. Ma, N., et al., Shape-Dependent Radiosensitization Effect of Gold Nanostructures in Cancer Radiotherapy: Comparison of Gold Nanoparticles, Nanospikes, and Nanorods. ACS Applied Materials & Interfaces, 2017, 9(15):13037-48.
銆€銆€20. Ho, L.W., Yet al., Effect of Alkylation on the Cellular Uptake of Polyethylene Glycol-Coated Gold Nanoparticles. ACS Nano, 2017.
銆€銆€21. Chen, Q., et al., Surface-Enhanced Raman Scattering from Self-Assembled Film of Thiolated Peg-Modified Gold Nanoparticles, Journal of Applied Spectroscopy, 2017, 84(3):407-12.
銆€銆€22. Garcia, J., New strategies based on nanosystems to facilitate the crossing through biological barriers, Universitat de Barcelona, 2016.
銆€銆€23. Kennedy, S., et al., Sequential release of nanoparticle payloads from ultrasonically burstable capsules, Biomaterials, 2016, 75, P. 91-101.
銆€銆€24. Liu, H., et al., Microfluidic synthesis of QD-encoded PEGDA microspheres for suspension assay, J. Mater. Chem. B, 2016.
銆€銆€25. Wang, Y.L., et al., The ordering alignment of gold nanorods in liquid crystals and its applications to polarization-sensitive SERS. InJournal of Physics: Conference Series, 2016, 680:1, p. 012021.
銆€銆€26. Zhang, B., et al., Conductive and protein resistant polypyrrole films for dexamethasone delivery, Journal of Materials Chemistry B, 2016.
銆€銆€27. Shendi, D., et al., Tunable, Bioactive Protein Conjugated Hyaluronic Acid Hydrogels for Neural Engineering Applications. Journal of Materials Chemistry B., 2016.
銆€銆€28. Zhang, Q., et al., Gold Nanoparticle (AuNP)-Based Surface-Enhanced Raman Scattering (SERS) Probe of Leukemic Lymphocytes, Plasmonics, 2016, 1-8.
銆€銆€29. Tian, L., et al., Plasmonic Nanogels for Unclonable Optical Tagging, ACS Applied Materials & Interfaces, 2016, 8 (6), 4031-4041.
銆€銆€30. Hu, W., et al., Redox and pH dual responsive poly(amidoamine) dendrimer-poly(ethylene glycol) conjugates for intracellular delivery of doxorubicin, Acta Biomaterialia, 2016, 36, p: 241-253.
銆€銆€31. Ding, H., et al., Intracellular Temperature Imaging in Gold Nanorod-Assisted Photothermal Therapy with Luminescent Eu (III) Chelate Nanoparticles. Journal of Nanoscience and Nanotechnology, 2016, 16(4):3877-82.
銆€銆€32. Wang, F., et al., Polydopamine鈥怓unctionalized Graphene Oxide Loaded with Gold Nanostars and Doxorubicin for Combined Photothermal and Chemotherapy of Metastatic Breast Cancer, Advanced Healthcare Materials, 2016.
銆€銆€33. Li, J., et al., SERS-active Plasmonic Nanoparticles with Ultra-small Interior Nanogap for Multiplex Quantitative Detection and Cancer Cell Imaging, Analytical Chemistry, 2016.
銆€銆€34. Pickenhahn, V. D., Regioselective thioacetylation of chitosan end-groups for nanoparticle gene delivery systemset al., Chem. Sci., 2015, 6, 4650-4664.
銆€銆€35. Fu, H., et al., Tumor鈥怲argeted Paclitaxel Delivery and Enhanced Penetration Using TAT 鈥怐ecorated Liposomes Comprising Redox鈥怰esponsive Poly(Ethylene Glycol), Journal of Pharmaceutical Science, 2015, 104(3): 1160-1173.
銆€銆€36. Sun, Y., et al., Patterning of graphite nanocones for broadband solar spectrum absorption, AIP Advances, 2015, 5, 067139.
銆€銆€37. Yuan, Y., et al., Topological nanocolloids with facile electric switching of plasmonic properties, Opt. Lett., 2015, 40, 5630-5633.
銆€銆€38. Wang, S., et al., Three-Photon Luminescence of Gold Nanorods and Its Applications for High Contrast Tissue and Deep In Vivo Brain Imaging. Theranostics, 2015, 5(3), 251-266.
銆€銆€39. Li, J., et al., Simple and Rapid Functionalization of Gold Nanorods with Oligonucleotides Using an mPEG-SH/Tween 20-Assisted Approach, Langmuir, 2015, 31 (28), 7869-7876.
銆€銆€40. Zhang, B., et al., Functionalised inherently conducting polymers as low biofouling materials, Biofouling, 2015, 31:6.
銆€銆€41. Wang, L., et al., Sea-Urchin-Like Au Nanocluster with Surface-Enhanced Raman Scattering in Detecting Epidermal Growth Factor Receptor (EGFR) Mutation Status of Malignant Pleural Effusion, ACS Applied Materials & Interfaces, 2015, 7 (1), 359-369.
銆€銆€42. Gao, L., et al., Plasmon-Mediated Generation of Reactive Oxygen Species from Near-Infrared Light Excited Gold Nanocages for Photodynamic Therapy in Vitro ACS Nano, 2014, 8(7), p: 7260–7271.
銆€銆€43. Li, J., Synergetic Approach for Simple and Rapid Conjugation of Gold Nanoparticles with Oligonucleotides, ACS Appl. Mater. Interfaces, 2014, 6(19), p. 16800–16807.
銆€銆€44. Mei, L., et al., Increased tumor targeted delivery using a multistage liposome system functionalized with RGD, TAT and cleavable PEG. International Journal of Pharmaceutics, 2014, 468(1–2), p. 26-38.
銆€銆€45. Hu, W., et al., Redox and pH-responsive poly (amidoamine) dendrimer-poly (ethylene glycol) conjugates with disulfide linkages for efficient intracellular drug release, Colloids Surf B Biointerfaces, 2014, 123, p:254-63.
銆€銆€46. Ai, X., et al., Thin-film hydration preparation method and stability test of DOX-loaded disulfide-linked polyethylene glycol 5000-lysine-di-tocopherol succinate nanomicelles, Asian Journal of Pharmaceutical Sciences, 2014, 9(5), p: 244-250.
銆€銆€47. Cui, J., et al., Nanoscale engineering of low-fouling surfaces through polydopamine immobilisation of zwitterionic peptides, Soft Matter, 2014, 10(15), 2656-2663.
銆€銆€48. Chen, S., et al., Nonionic fluorosurfactant as an ideal candidate for one-step modification of gold nanorods, Nanoscale, 2014, 6, 3197-3205.
銆€銆€49. Yuan, W., et al., Increased Delivery of Doxorubicin Into Tumor Cells Using Extracellularly Activated TAT Functionalized Liposomes: In Vitro and In Vivo Study, Journal of Biomedical Nanotechnology, 2014, 10:8, p. 1563-1573(11).
銆€銆€50. Tang, J., et al., Liposomes co-modified with cholesterol anchored cleavable PEG and octaarginines for tumor targeted drug delivery, Journal of Drug Targeting, 2014, 22:4.
銆€銆€51. Ai, X., et al., Star-Shape Redox-Responsive PEG-Sheddable Copolymer of Disulfide-Linked Polyethylene Glycol-Lysine-di-Tocopherol Succinate for Tumor-Triggering Intracellular Doxorubicin Rapid Release: Head-to-Head Comparison, Macromol. Biosci., 2014, 14: 1415–1428.
銆€銆€52. Ni, D., et al., Dual-targeting upconversion nanoprobes across the blood–brain barrier for magnetic resonance/fluorescence imaging of intracranial glioblastoma, ACS nano, 2014, 8(2):1231-42.
銆€銆€53. Yang, L., et al., Luminescent Ru(bpy)3 2+-doped silica nanoparticles for imaging of intracellular temperature, Microchimica Acta, 2013, 181:7, p. 743-749.
銆€銆€54. Taylor, W., et al., Protein Adsorption on Well-Characterized Polyethylene Oxide Brushes on Gold: Dependence on Molecular Weight and Grafting Density, Langmuir, 2013, 29(20), p: 6116–6122.
銆€銆€55. Molino, P. J., et al., Surface modification of polypyrrole/biopolymer composites for controlled protein and cellular adhesion, Biofouling, 2013, 29 (10), 1155-1167.
銆€銆€56. Yue, Z., et al., PEGylation of platinum bio-electrodes. Electrochemistry Communications, 2013, 27, 54-58.
銆€銆€57. Qin, H., et al., Gadolinium (III)-gold nanorods for MRI and photoacoustic imaging dual-modality detection of macrophages in atherosclerotic inflammation, Nanomedicine, 2013, 8.10: 1611-1624.
銆€銆€58. Kuai, R., et al., Targeted Delivery of Cargoes into a Murine Solid Tumor by a Cell-Penetrating Peptide and Cleavable Poly(ethylene glycol) Comodified Liposomal Delivery System via Systemic Administration, Mol. Pharmaceutics, 2011, 8(6), p: 2151–2161.
銆€銆€59. Wang, B., et al., Polymer Single Crystal Templated Janus Nanoparticles, Macromol. Rapid Commun., 2010, 31: 169–175.
銆€銆€60. Tsai, D.H., et al., Competitive Adsorption of Thiolated Polyethylene Glycol and Mercaptopropionic Acid on Gold Nanoparticles Measured by Physical Characterization Methods, Langmuir, 2010, 26 (12), 10325-10333.
銆€銆€61. Kuai, R., et al., Efficient Delivery of Payload into Tumor Cells in a Controlled Manner by TAT and Thiolytic Cleavable PEG Co-Modified Liposomes, Molecular Pharmaceutics, 2010, 7 (5), 1816-1826.
銆€銆€62. Taylor, W., et al., Producing High-Density High-Molecular-Weight Polymer Brushes by a “Grafting to” Method from a Concentrated Homopolymer Solution, Langmuir, 2010, 26 (17), 13954-13958.
銆€銆€63. Li, B., et al., Programmable Nanoparticle Assembly via Polymer Single Crystals, Macromolecules, 2009, 42 (24), 9394-9399.
銆€銆€64銆丩iu, Y., et al., Cathodic protected Mn2+ by NaxWO3 nanorods for stable magnetic resonance imaging-guided tumor photothermal therapy, Biomaterials, 2020, V. 234.
銆€銆€65.Guo, T., et al., Highly-selective detection of EGFR mutation gene in lung cancer based on surface enhanced Raman spectroscopy and asymmetric PCR, Journal of Pharmaceutical and Biomedical Analysis, 2020, 190,113522.
66. Wang, X.-M., et al., Exposure-time-dependent subcellular staging of gold nanoparticles deposition and vesicle destruction in mice livers, Nanomedicine: Nanotechnology, Biology and Medicine, 2021, V. 34.
67.Morales-Zavala, F., et al., In vivo micro computed tomography detection and decrease in amyloid load by using multifunctionalized gold nanorods: a neurotheranostic platform for Alzheimer's disease. Biomaterials Science. 2021.
68.Cai, X., et al., Synthesis of Au@ MOF Core-Shell Hybrids for Enhanced Photodynamic/Photothermal Therapy. Journal of Materials Chemistry B. 2021.
69.Ahmad, T., et al. Development of wound healing scaffolds with precisely-triggered sequential release of therapeutic nanoparticles.
70.Zhang, Y., et al., DNA-assembled visible nanodandelions with explosive hydrogen-bond breakage achieving uniform intra-tumor distribution (UITD)-guided photothermal therapy, Biomaterials, 2022, 121381.
71.Robert, J, et al., Coiled-Coil Peptide-Based Assembly of a Plasmonic Core-Satellite Polymer-Metal Nanocomposite as an Efficient Photothermal Agent, NANOTODAY-D-22-00764, 2022.
72.Robert, J., et al., Coiled-coil peptide-based assembly of a plasmonic core-satellite polymer-metal nanocomposite as an efficient photothermal agent for drug delivery applications, Journal of Colloid and Interface Science, 641, 2023.
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