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LNP鍦ㄤ綋鍐呭缁嗚優杩涜鏀归€犲拰閲嶇紪绋嬶紝鑳藉閬垮厤浼犵粺浣撳CAR缁嗚優鐤楁硶鐨勪竴绯诲垪澶嶆潅浣撳娴佺▼锛屽ぇ骞呭害闄嶄綆鍒跺闅惧害鍜屾垚鏈紝鎰忓懗鐫€鏇村粔浠枫€佹洿鏄撹幏寰楃殑涓€у寲娌荤枟鏂规銆傚彟澶栵紝鐢变簬mRNA涓嶄細杩涘叆缁嗚優鏍革紝涓嶄細瀵筎缁嗚優鐨凞NA杩涜缂栬緫锛屽洜姝ゆ墍鏀归€犵殑CAR缁嗚優浠呭叿鏈夋暟澶╃殑鏀诲嚮鎬э紝閲嶅叿鏈夋綔鍦ㄧ殑鍙帶瀹夊叏鎬у拰鑰愬彈鎬с€侟/p> <p>銆€銆€鍚屾椂锛屾垜浠篃搴旂湅鍒帮紝浣滀负涓€绉嶅叏鏂扮殑鎶€鏈矾绾匡紝璇ユ妧鏈湪瀹為檯搴旂敤浜庢不鐤椾腑浠嶇劧瀛樺湪澶ч噺鍙兘鐨勯棶棰樸€傚瀵逛簬鐧岀棁鎮ｈ€呮潵璇达紝涓村簥鍏ョ粍鐨勭檶鐥囨偅鑰咃紝澶у鍦ㄦ鍓嶅凡缁忔帴鍙椾簡澶氱嚎娌荤枟锛屼綋鍐呭厤鐤粏鑳炵殑鏁伴噺鍜岃川閲忓凡缁忓緢宸紝鑳藉惁瀵逛簬mRNA LNP浜х敓鍝嶅簲锛屼互浜х敓瓒冲鐨凜AR鍏嶇柅缁嗚優杩涜鑲跨槫鏉€浼ゅ皻灞炴湭鐭ャ€傛澶栵紝闈跺悜鎬ч棶棰樸€侀€掗€佹晥鐜囬棶棰樸€佹瘨鎬ч棶棰樼瓑閮芥槸璇ユ妧鏈湪瀹為檯鎶曞叆搴旂敤涔嬪墠蹇呴』瑙ｅ喅鐨勯棶棰樸€侟/p> <p>銆€銆€[1]JOEL G. RURIK et al. CAR T cells produced in vivo to treat cardiac injury. 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